Ability to Exclude Criteria in Queries

It would be really helpful when adding filters (either to the Insights, Accounting or Transactions tabs) to be able to EXCLUDE certain items. For example - I want to show all transactions that are charged to any cost center except 00000-Not Specified. As far as I can tell, the only way to do that currently is to select everything but that option. Would be much more efficient if I could just select one thing and say, everything except that.